ORCHARD PARK, N.Y. -- Buffalo Bills offensive tackle Seantrel Henderson is facing a four-game NFL suspension for violating the leagues substance-abuse policy, a source told ESPN NFL Insider Adam Schefter.The positive test was apparently caused by a treatment for Crohns disease and the suspension is under appeal, a source told Schefter. While some reports have indicated marijuana was the cause of the positive test, sources tell ESPN marijuana is only part of the equation.Bills coach Rex Ryan wouldnt comment on specifics of the suspension, but he said the team would fill the void.Well be prepared for whatever happens, obviously, he said. For us, any time, with any situation, our board is set up to where you got the top free agents available -- whatever the situation is, through injury or whatever -- our pro personnel department is on top of it.Henderson, 24, tested positive for marijuana at the NFL combine in 2014, a source told Schefter. He also was suspended while playing at the University of Miami for failed drug tests. Hendersons history with substance abuse caused some teams to remove him from their draft boards.Ryan said the Bills have a program in place to steer players clear of danger.Well I think, first off, were not perfect by any stretch of the imagination, but we try to provide our players with -- I think our player program department, we bring in speakers, we try to have, even through the league theres things set up, he said. But unfortunately weve had some issues.The Bills selected Henderson with their seventh-round pick in 2014. He started all 16 games at right tackle as a rookie and started 10 of the Bills first 11 games last season, missing one game in October with a concussion.Henderson missed the final five games of last season after he was diagnosed with Crohns disease, an inflammatory condition that affects the digestive system.The third-year tackle told The Palm Beach Post last month that he underwent surgery in January to remove 2? feet of his intestines, resulting in him losing nearly 50 pounds and having to wear an ileostomy bag until his intestines were reattached in April.I was weak, Henderson told the newspaper. At first I couldnt stand up on my own. I felt so weak. It was terrible. I didnt like it at all. I kept walking and walking around the hospital.Hendersons weight dropped to 281 following the surgery, but he regained most of his lost weight by the time he returned to practice Aug. 22. He is now on a strict diet that prevents him from eating gluten or certain vegetables.Jordan Mills replaced Henderson in the starting lineup late last season and remains the Bills projected starter this season. Henderson has mostly taken snaps with the second team since returning to practice.Hendersons suspension is the teams third substance-abuse suspension since the summer. Former running back Karlos Williams was suspended four games in July and later released, while Pro Bowl defensive tackle Marcell Dareus will miss the first four games of this season for what he called a missed drug test. Under Armour Outlet Sale . Pettersen, winner of last years Evian Championships, had nine birdies and three bogeys, holding off a series of challengers led by Marion Ricordeau of France. The second-ranked Norwegian made her season debut after missing the LPGA Tours opening event last month in the Bahamas because of a shoulder injury. Wholesale Under Armour Shop . 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